Rheumatology Quiz

Sonal Mehra MD, DM
Centre for Rheumatology Arthritis and Spine, Noida

1. All the following drugs have been associated with drug induced psoriasis except

A. Lithium
B. Hydroxychloroquine
C. Propranolol
D. Fluconazole

2. What is the downstream effect of Riociguat’s mechanism of action?

A. Increased cAMP levels
B. Increased cGMP levels
C. Decreased nitric oxide production
D. Enhanced calcium influx into cell

3. The Classic Wiskott-Aldrich Syndrome an X-linked disorder, is associated with all of the following condition except

A. Increased bleeding due to small sized platelets
B. Recurrent bacterial, viral, and fungal infections
C. Eczema
D. Asthma

4. All the following are the humoral immunodeficiencies, except

A. Immunodeficiencies with hyper IgM
B. X-Linked Agammaglobulinemia (XLA)
C. DiGeorge syndrome (thymic hypoplasia)
D. Selective immunoglobulin deficiencies (IgM, IgG, IgA)

5. Difficult-to-treat rheumatoid arthritis (D2T-RA) is defined as failure of at least how many different mechanisms of action?

A. One
B. Two
C. Three
D. Four

6. What is the absolute risk for developing spondyloarthropathies in individuals who are positive for the HLA-B27 gene?

A. Up to 10%
B. Up to 20%
C. Up to 40%
D. Up to 80%

7.Which statement regarding cancer rates for Tofacitinib and other JAK inhibitors is most accurate?

A. Cancer rates are similar between 5-mg and 10-mg daily dosing of tofacitinib.
B. Cancer rates were significantly higher for JAK inhibitors compared with placebo.
C. Cancer rates for tofacitinib increased throughout use.
D. Cancer rates for tofacitinib increased throughout use.

8. Remibrutinib, a potent oral covalent BTK inhibitor has a role in all of the following except

A. Chronic spontaneous urticaria
B. Allergic asthma
C. Sjogren’s syndrome
D. Psoriatic Arthritis

9. Delayed hypersensitivity reactions to monoclonal antibodies include which of the following mechanism

A. Cytokine-release
B. IgE-mediated
C. Infusion reactions
D. Serum sickness-like

10. Romosozumab (humanized monoclonal antibody sclerostin inhibitor) is contraindicated in patients with all of the following except

A. Hypocalcemia
B. History of stroke or myocardial infarction in the past year
C.Renal Impairment
D. Hypersensitivity 

Answer Key:

01. D
02. B
03. D
04. C
05. B
06. A
07. A
08. D
09. D
10. C